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Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons

Ajmer Singh Grewal (Guru Gobind Singh College of Pharmacy, Yamuna Nagar, India), Ashwani Kumar Dhingra (Global Research Institute of Pharmacy, India), Kunal Nepali (Taipei Medical University,Taipei, Taiwan), Geeta Deswal (Guru Gobind Singh College of Pharmacy, Yamuna Nagar, India), and Arun Lal Srivastav (Chitkara University, India)
Indexed In: SCOPUS
Release Date: March, 2024 | Copyright: © 2024 | Pages: 422

Publication Status: E-Book and Print Version Available for Purchase
ISBN13: 9798369341391
ISBN13 Softcover: 9798337346854
EISBN13: 9798369341407
DOI: 10.4018/979-8-3693-4139-1

Description:

The rise of modern antimicrobial drug resistance has evolved into a pressing global health crisis, challenging the very foundation of our ability to combat infectious diseases. The overuse and accessibility of antibiotics, particularly in emerging nations, have given rise to resilient "superbugs," rendering common medications ineffective. This escalating challenge poses a significant threat to public health and leads to heightened healthcare costs, prolonged patient stays, and increased mortality rates. As communities grapple with the urgent need for a coordinated response, a comprehensive understanding of antimicrobial drug resistance and innovative strategies becomes paramount.

Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons is meticulously crafted for academic scholars, researchers, and healthcare professionals. It addresses this critical issue head-on and serves as a beacon of knowledge and a solution-oriented guide. With a focus on elucidating the mechanisms behind antimicrobial drug resistance and exploring emerging therapeutic targets, the book presents an in-depth analysis of the problem. It spans environmental, genetic, and climatic factors influencing resistance, delving into cutting-edge technologies and sustainable strategies for prevention. By offering a holistic view of the issue and proposing evidence-based solutions, the book is an indispensable resource for those seeking to navigate the complex landscape of antimicrobial drug resistance.

Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons aims to raise awareness, guide policy decisions, and foster international cooperation. It is a comprehensive educational tool, equipping students, researchers, and healthcare professionals with the knowledge needed to tackle this global menace. Ultimately, the book's contribution lies in understanding the complexities of antimicrobial drug resistance and empowering individuals and communities to enact meaningful change in the face of this formidable challenge.

Coverage:

The many academic areas covered in this publication include, but are not limited to:

  • Aminoglycoside-Modifying Enzymes
  • Antibiotic Resistance
  • Antimicrobial Drug Resistance
  • Beta-Lactamase Inhibitors
  • Biofilm Targeting Strategies
  • Climatic Variations
  • Computational Biology
  • COVID-19
  • Ecological Disturbances
  • Efflux Pump Inhibitors
  • Environmental Factors
  • Genetic Factors
  • Lantibiotics
  • Nanocarriers
  • Prevention Strategies

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Ajmer Singh Grewal is working as Professor at the Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana (India) since Mar. 02, 2021. He had worked as Assistant Professor at the School College of Pharmacy, Chitkara University (Himachal Pradesh) from July 2019 to February 2021 and at Chitkara College of Pharmacy, Chitkara University (Punjab) from March 2017 to June 2019. Before that, he had worked as Assistant Professor at Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa (Haryana, India) from November 2011 to February 2017. He is a dedicated academic professional with experience of 14+ years committed to pharmaceutical education. He had taught B. Pharm., M. Pharm. and Pharm. D. students and supervised 08 M. Pharm. (Pharmaceutical Chemistry) students in the research area of Drug Design and Medicinal Chemistry. He is currently guiding 03 PhD students in the area of Drug Design and Discovery. He had completed PhD in Pharmaceutical Sciences in the subject area of Computational and Medicinal Chemistry on the project entitled “Design, Synthesis and Biological Evaluation of Newer Glucokinase Activators” from I.K. Gujral Punjab Technical University, Jalandhar (Punjab) in 2019. Earlier, He had seasoned Master of Pharmacy in Pharmaceutical Chemistry on the project entitled “Development and Validation of New Analytical Methods for Estimation of Selected Drugs in Bulk & Pharmaceutical Formulations” from the Institute of Pharmacy and Technology, Salipur, Cuttack in 2011. He had qualified for GATE-2009 (87.09 percentile). His present areas of research include rational drug design and medicinal chemistry of matrix metallo-proteinase (MMP2 and MMP9) inhibitors as anticancer agents, antibacterial drug resistance (NDM-1 inhibitors), glucokinase activators as anti-diabetic agents, aldose reductase inhibitors for diabetic complications, PPAR agonists for the treatment of metabolic syndrome, multi-potent anti-Alzheimer’s agents, selective PDE-4 & PDE-7 inhibitors as anti-inflammatory agents and environmental chemistry. He owns to his credit more than 100 articles in national and international journals of repute, 22 book chapters, 16 books, 6 patents (3 granted & 3 published), 2 design patents and various poster presentations (16) at several conferences (both national and international). Currently, he is editing 7 books with Nova Science, Elsevier and IGI Global.
Ashwani Kumar is presently working as Principal, Global Research Institute of Pharmacy, Yamuna Nagar. Professionally, he is a Medicinal Chemist with expertise in the design and development of synthetic methodologies dealing with various organic transformations, multistep synthesis of medicinally active heterocyclics along with bioactive natural product analogs. He has done PhD in Pharmaceutical Sciences from IKGPTU University, Jalandhar and M. Pharm in Pharmaceutical Chemistry from ISF College of Pharmacy affiliated to PTU, Jalandhar. He is an alumnus of GGSCOP, Yamuna Nagar at graduate level. He has 15+ years of teaching experience. His expertise in the Computer Aided Drug Design, Analytical Method Development and Validation; Natural Product Chemistry, Formulation Development using NDDS field enabled him to conduct research in areas of diverse nature. His research areas include like molecular docking, pharmacophore modelling, virtual screening, pharmaceutical quality control, pharmaceutical technology and synthesis of medicinally active compounds. His expertise is simply recognized by the fact that he is acting as referee for review of manuscripts for large number of international journals of repute. He has more than 90 research/review publications - most of them in international journals of repute to his credit in addition to 06 books with international Publishers, 08 patent (Design), 05 patents (Formulation) and 11 copyrights. He is a recipient of project grant (Rs. 7,00,000/-) under MSME Innovative Scheme (Incubation, Design & IPR) in 2022; Training grant (Rs. 50,000/-) from Pharmacy Council of India, New Delhi under PCI CBIT Scheme in 2021 and Conference grant (Rs. 20,000/-) from Patent Felicitation Centre, HSCST, DST, Govt. of Haryana for conducting one day national workshop on Patents filing procedure for students and small-scale industries in 2019.He is honored asLate Prof. (Dr.) M. L. Shroff “Pharma Recognition Award” by PharmaLok (NGO), New Delhi in 2022; Innovational Ambassador (Design Thinking & Innovation) by MHRD Innovational Cell, AICTE, New Delhi in 2021; Bentham Ambassador (2022-23, 2020-2021, 2019-20) by Bentham Science Publishers; e-certificate for Highly Cited Research in Fitoterapia by Elsevier in 2016.He is Life Member of the Indian Society for Technical Education (LM - 136464); Association of Pharmaceutical Teachers in India (HA/LM-153); Education Research and Development Association (ERDA/INDLM/792/1223) and Society for Research Development in Health Sciences (SRDHS/11).He has delivered more than 20 guest talks on various topics of healthcare domain in collaboration with different Government and Non-government organizations.
Kunal Nepali is an Associate Professor in the School of Pharmacy, Taipei Medical University, Taiwan. Dr. Kunal joined the School of Pharmacy, Taipei Medical University as an Assistant Professor on 17.01.2019 and is currently handling independent research projects funded by the Ministry of Science and Technology (MOST) as well as Taipei Medical University. He has expertise spanning medicinal chemistry and organic synthesis with ten years of experience in a broad range of drug development projects. He obtained his PhD degree in Pharmaceutical Chemistry in the year 2012 from ISF College of Pharmacy, Moga, Punjab. During his doctoral studies, he worked under the supervision of Dr. K.L Dhar, a pioneer organic and medicinal chemist of India and systematically explored various areas of rational drug design and natural product chemistry. Along with the teaching assignments, he was actively involved in research projects and explored various areas of Catalytic Chemistry and Medicinal Chemistry. With an overwhelming stint as a teacher and a researcher, he was determined to expand the horizon of his expertise by gaining international exposure. To accomplish this, he moved to Taipei Medical University, Taiwan in October 2014 as a post-doctoral fellow in the laboratories of Professor Jing Ping Liou. His research work at the post-doctoral level involved the design of new chemical entities with desired biological activities and the development/optimization of synthetic procedures for the preparation of compounds along with structure-activity relationship studies. It was his exemplary research work at the post-doctoral level that earned him a highly competitive faculty position at the School of Pharmacy, Taipei Medical University. He made a significant contribution to the field of Medicinal Chemistry throughout his post-doctoral tenure and earned the outstanding Post-Doctoral Researcher award, Taipei Medical University for five consecutive times from 2014 to 2018. He is the author of a good number of research/review articles and is an ad-hoc reviewer of various reputed journals in the field of biomedical sciences. He has also received various recognitions as a reviewer for Medicinal Research Reviews, European Journal of Medicinal Chemistry, Bioorganic Chemistry, Bioorganic and Medicinal Chemistry Letter, and others.
Geeta Deswal holds a Ph.D. in Pharmaceutical Sciences from MM University, Mullana, Ambala, Haryana, awarded in 2017 under the guidance of Prof. (Dr.) Vipin Saini. She completed her M.Pharm in Pharmacognosy in 2011 and B.Pharm in 2009, both from the same institution. Currently, Dr. Deswal serves as a Professor and Head of the Department of Pharmacognosy at Guru Gobind Singh College of Pharmacy, Yamuna Nagar. In addition, she functions as the Internal Quality Assurance Cell (IQAC) and NBA Coordinator for the institution. Dr. Deswal has made significant academic contributions through her extensive list of 39 publications in reputed journals, focusing on phytochemical screening, plant tissue culture, herbal formulation quality audits, and therapeutic applications of natural compounds. Her research also extends to molecular docking, nanotechnological strategies, and biodegradable polymer applications in cancer therapy. She has co-authored and edited 10 books, including: A Practical Book of Pharmaceutical Organic Chemistry (2024, ISBN: 978-9-36109-206-0). Nature’s Arsenal Against Cancer: Harnessing the Power of Natural Compounds for Treatment and Prevention (2024, ISBN: 979-8-89530-202-6). Naturally Occurring Chemicals for the Treatment and Management of Diabetes Mellitus and Related Disorders (2024, ISBN: 979-8-89113-491-1). Dr. Deswal has also contributed to numerous book chapters, such as: Nanoparticles for the Treatment of Cancer in Current Therapeutic Strategies for the Management of Cancer (2023, ISBN: 979-8-89113-133-0). Resveratrol: A Phytocentric Overview of Potential in Metabolic Syndrome in Natural Products for Treatment of Metabolic Syndrome (2022, ISBN: 979-8-88697-152-1). Her work has been supported by research grants and consultancy projects, and she has received several awards, including the “Young Achiever Award.” Dr. Deswal continues to excel in pharmaceutical education and research, particularly in advancing the therapeutic use of natural compounds.
Arun Lal Srivastav works as an Associate Professor at Chitkara University, Himachal Pradesh, India. He obtained Ph.D. degree from the Indian Institute of Technology (BHU), Varanasi, India. He has done post-doctoral research at National Chung Hsing University, Taiwan. He is currently involved in teaching Environmental Science, Environmental Engineering, Disaster Management, and Design Thinking to undergraduate engineering students. His research interests include Water Quality Surveillance, Climate Change, Water Treatment, River Ecosystems, Soil Health, Phytoremediation and Waste Management. He has published over 80 research papers in various prestigious journals (Elsevier, Springer Nature, IWA, Wiley, etc.), including book chapters and conference papers. He is the editor of 17 books with Elsevier, Nova, Springer, IGI Global, and Wiley.

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